Prabhu, Vilas A. published the artcileSynthesis and structure-activity relationships of selected tricyclic oxime O-ethers as potential anticholinergic agents, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, the publication is Journal of Pharmaceutical Sciences (1981), 70(5), 558-62, database is CAplus and MEDLINE.
The thioxanthone oximes I [R = CH2CH2NMe2, 1-methyl-4-piperidinyl, (CH2)3NMe2, CH2CHMeNMe2, CHMeCH2NMe2], prepared by alkylation of thioxanthone oxime with the appropriate aminoalkyl halides in the presence of NaH, exhibited significant antimuscarinic activity in rat ileum. However, (±)-I (R = CH2CHMeNMe2) was at least 5 times more potent than the corresponding O-(α-methylcholine) ether derivative of benzophenone oxime whereas (±)-I (R = CHMeCH2NMe2) was the least active among I.
Journal of Pharmaceutical Sciences published new progress about 4584-49-0. 4584-49-0 belongs to chlorides-buliding-blocks, auxiliary class Chloride,Salt,Amine,Aliphatic hydrocarbon chain, name is 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride, and the molecular formula is C5H13Cl2N, Recommanded Product: 2-Chloro-N,N-dimethylpropan-1-amine hydrochloride.
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