Yuen, Tsz Ying published the artcileSynthesis of chiral alkenyl cyclopropane amino acids for incorporation into stapled peptides, Quality Control of 5034-06-0, the publication is Journal of Organic Chemistry (2020), 85(3), 1556-1566, database is CAplus and MEDLINE.
α,α’-Disubstituted amino acids serve as important non-proteinogenic amino acids in the construction of stabilized helical peptides. To expand the repertoire of α,α’-disubstituted amino acids, chiral alkenyl-containing cyclopropane amino acids were synthesized via a two-step olefination and cyclopropanation procedure. Herein, we report the first example of the use of alkenyl cyclopropane building blocks to constrain MDM2-targeting helical peptides. The increased potency and efficacy associated with C-terminal cyclopropane substitution is postulated to be driven by a combined effect of net hydrophobicity and enhanced protein association rates.
Journal of Organic Chemistry published new progress about 5034-06-0. 5034-06-0 belongs to chlorides-buliding-blocks, auxiliary class Salt,Aliphatic hydrocarbon chain, name is trimethyloxosulphonium chloride, and the molecular formula is C5H5NO3S, Quality Control of 5034-06-0.
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