Design, synthesis, and antifungal evaluation of novel coumarin-pyrrole hybrids was written by Zhang, Shuguang;Tan, Xin;Liang, Chaogen;Zhang, Weihua. And the article was included in Journal of Heterocyclic Chemistry in 2021.Related Products of 638-07-3 The following contents are mentioned in the article:
A series of coumarin derivatives I [R1 = H, CH3, CH2CH3, Cl; R2 = H, CH3, CF3, CH2Cl, (CH2)2CH3; R3 = H, CH3, OH; R4 = H, CH3; R5 = H, CH3; R1R2 = -(CH2)3-] bearing a pyrrole scaffold was designed, prepared, and assessed for their in vitro antifungal activities against six phytopathogenic fungi. The antifungal activity screening results suggest that some synthesized hybrids exhibited potential fungicidal activities against the tested fungi. In particular, compounds I (R1 = R5 = H, R2 = CH3, R3 = OH, R4 = CH3; R1 = R5 = H, R2 = (CH2)2CH3, R3 = OH, R4 = CH3; R1 = R4 = H, R2 = R3 = R5 = CH3; R1 = R4 = H, R3 = R5 = CH3, R2 = CF3; R1 = R4 = H, R3 = R5 = CH3, R2 = (CH2)2CH3) displayed significant antifungal effects against Rhizoctonia solani, and possessed EC50 values of 3.94, 7.75, 6.38, 6.25, and 7.67μg/ mL, resp. The above activities are more potent than the commercialized fungicide Boscalid (11.52μg/mL) and Osthole (9.79μg/mL). These results provide a significant reference for further rational design of coumarin-based fungicides. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Related Products of 638-07-3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Related Products of 638-07-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics