Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection was written by Guo, Yuying;Chen, Jiabao;Ren, Dan;Du, Bo;Wu, Lei;Zhang, Yuanyuan;Wang, Zhouyu;Qian, Shan. And the article was included in Bioorganic & Medicinal Chemistry in 2021.Electric Literature of C6H5ClO2 The following contents are mentioned in the article:
Plant pathogenic fungi decrease the quality and productivity of plant production The botanical fungicides have better biocompatibility and rapid biodegradation, little or no cross resistance, and the structural diversity, and thus are beneficial to deal with plant fungal diseases. Osthole has been widely used as the com. botanical fungicide against powdery mildew in China. In this article, a series of osthole derivatives were synthesized, which resp. contain different substituents on the benzene ring, at the C8-position and pyrone ring. All the target compounds were evaluated in vitro for their antifungal activity against resistant phytopathogenic fungi. Colletotrichum fragariae, Strawberry Botrytis cinerea, Kiwifruit Botrytis cinerea, Kiwifruit brown Rots, which are common in fruit fungal diseases. The compound 7-hydroxy-8-methyl-4-(trifuoromethyl)-2H-chromen-2-one (I) was identified as the most promising candidate with the EC50 values at 38.7μg/mL against Colletotrichum Fragariae, 14.5μg/mL against Strawberry Botrytis Cinerea and 24.3μg/mL against Kiwifruit Botrytis Cinerea, resp., whereas the antifungal activity against resistant phytopathogenic fungi. of osthole is too low to be used (EC50 > 400 ppm). The results of mycelial relative conductivity determination, PI uptake and fluorescence spectroscopy indicated that the cell membrane of fungi is the key action site of I. Besides, I has the potent inhibitory activity against both of plant and human pathogenic bacteria. Our studies showed that C4 was worthy for further attention as a promising botanical fungicide candidate in crop protection. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Electric Literature of C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Electric Literature of C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics