Rational Identification of Hsp90 Inhibitors as Anticancer Lead Molecules by Structure Based Drug Designing Approach was written by Gupta, Sayan D.;Swapanthi, Pappu S.;Bhagya, Deshetti;Federicci, Fernando;Mazaira, Gisela I.;Galigniana, Mario D.;Subrahmanyam, Chavali V. S.;Gowrishankar, Naryanasamy L.;Raghavendra, Nulgumnalli M.. And the article was included in Anti-Cancer Agents in Medicinal Chemistry in 2020.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:
Heat shock protein 90 (Hsp90) is an encouraging anticancer target for the development of clin. significant mols. Schiff bases play a crucial role in anticancer research because of their ease of synthesis and excellent antiproliferative effect against multiple cancer cell lines. Therefore, we started our research work with the discovery of resorcinol/4-chloro resorcinol derived Schiff bases as Hsp90 inhibitors, which resulted in the discovery of a viable anticancer lead mol. The objective of the study is to discover more promising lead mols. using our previously established drug discovery program, wherein the rational drug design is achieved by mol. docking studies. The docking studies were carried out by using Surflex Geom X program of Sybyl X-1.2 version software. The mols. with good docking scores were synthesized and their structures were confirmed by IR, 1H NMR and mass spectral anal. Subsequently, the mols. were evaluated for their potential to attenuate Hsp90 ATPase activity by Malachite green assay. The anticancer effect of the mols. was examined on PC3 prostate cancer cell lines by utilizing 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay methodol. Schiff bases 11, 12, 20, 23 and 27 exhibiting IC50 value below 1μM and 15μM, in malachite green assay and MTT assay, resp., emerged as viable lead mols. for future optimization. The research work will pave the way for the rational development of cost-effective Schiff bases as Hsp90 inhibitors as the method employed for the synthesis of the mols. is simple, economic and facile. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 4-Chlororesorcinol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics