Hu, Chun-Fang et al. published their research in Bioorganic Chemistry in 2020 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: Ethyl 4-chloro-3-oxobutanoate

Ethylenic conjugated coumarin thiazolidinediones as new efficient antimicrobial modulators against clinical methicillin-resistant Staphylococcus aureus was written by Hu, Chun-Fang;Zhang, Peng-Li;Sui, Yan-Fei;Lv, Jing-Song;Ansari, Mohammad Fawad;Battini, Narsaiah;Li, Shuo;Zhou, Cheng-He;Geng, Rong-Xia. And the article was included in Bioorganic Chemistry in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Ethylenic conjugated coumarin thiazolidinediones as potential multi-targeting new antimicrobial compounds I [R1 = H, Me; R2 = H, Et, CH2HC=CH2, 4-FC6H4CH2, etc.; R3 = H, CH2HC=CH2, CH2C≡CH] were synthesized through convenient procedures from com. available resorcinol and were evaluated for their antimicrobial potency. Bioactive evaluation revealed that some of the prepared compounds I showed strong antimicrobial activities toward the tested microorganisms including clin. drug-resistant strains. Especially, propargyl derivative I [R1 = Me; R2 = CH2C≡CH; R3 = H] exhibited effective anti-MRSA potency with MIC value of 0.006μmol/mL, which was highly advantageous over clin. antibacterial drug norfloxacin. Compound I [R1 = Me; R2 = CH2C≡CH; R3 = H] showed rapid killing effect, low toxicity against hepatocyte LO2 cell line and no obvious drug resistance development against MRSA. Preliminary exploration of action mechanism manifested that compd I [R1 = Me; R2 = CH2C≡CH; R3 = H] acted upon MRSA through forming stable supramol. complex with bacterial DNA which might impede DNA replication. Mol. docking showed that compound I [R1 = Me; R2 = CH2C≡CH; R3 = H] could bind with DNA-gyrase through hydrogen bonds. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Name: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics