Li, Yang et al. published their research in Molecular Diversity in 2020 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 638-07-3

Application of 2,4-bis(halomethyl)quinoline: synthesis and biological activities of 2,4-bis(benzofuran-2-yl)- and 2,4-bis(aroxymethyl)quinolines was written by Li, Yang;Xu, Qiqi;Li, Zhiyuan;Gao, Wentao;Chen, Yu. And the article was included in Molecular Diversity in 2020.Reference of 638-07-3 The following contents are mentioned in the article:

The synthesis of a new type of halomethylquinoline building block, i.e., Et 4-(bromomethyl)-2-(chloromethyl)quinoline-3-carboxylate, and its synthetic applications in the reaction with salicylaldehydes/o-acetylphenols R-2-HOC6H3C(O)R1 [R = H, 5-MeO, 5-C(CH3)3, 3-F-5-C(CH3)3, etc.; R1 = H, Me] or phenols R2C6H4OH [R2 = H, 2-Me, 4-MeO, 2-F, 2-F-4-C(CH3)3, etc.] to make a range of structurally novel and intriguing 2,4-bis(benzofuran-2-yl)quinoline- I [R3 = 7-F-5-C(CH3)3, 7-Br-5-C(CH3)3, 3-Me-5-Br, etc.] and 2,4-bis(aroxymethyl)quinoline-3-carboxylic acids II is described. This newly synthesized compounds belong to a new class of quinoline derivatives, and their structures were elucidated on the basis of their spectral data and elemental analyses. Screening for in vitro anti-tubercular against Mycobacterium smegmatis and anti-bacterial activities against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa was carried out. Compounds I [R2 = 7-F-5-C(CH3)3 and 7-Br-5-C(CH3)3] showed significant anti-tubercular activity comparable with the reference rifampicin and might be used as promising candidates for further investigation. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Reference of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics