Design, synthesis, and biological evaluation of novel bromo-pyrimidine analogues as tyrosine kinase inhibitors was written by Munikrishnappa, Chandrashekar S.;Suresh Kumar, G. V.;Bhandare, Richie R.;Shaik, Afzal B.. And the article was included in Arabian Journal of Chemistry in 2021.HPLC of Formula: 638-07-3 The following contents are mentioned in the article:
In the present investigation a novel series of bromo-pyrimidine analogs I (R = Ph, 2-furyl, 3-ClC6H4, etc.; R1 = H, Me), II (R = Ph, 4-F3CC6H4, 4-FC6H4, etc.) and III (R = Ph, 4-ClC6H4, 3-pyridinyl, etc.) are designed, synthesized and evaluated as anticancer agents. The compounds were characterized using spectroscopic studies and elemental anal. and screened for their in vitro cytotoxic activity by MTT assay against four cancer cell lines including HCT116 (human colon cancer cell line), A549 (human lung cancer cell line), K562 (human chronic myeloid leukemia cell line), U937 (human acute monocytic myeloid leukemia cell line) as well as the normal human liver cell line, L02. Most of the compounds showed potent activity on K562 cells. Considering this, the compounds were evaluated for Bcr/Abl tyrosine kinase inhibitory activity by ADP-Glo assay. Dasatinib was used as standard drug for both cytotoxicity and tyrosine kinase inhibition studies. The compounds, I (R = 4-F3CC6H4; R1 = H), I (R = 4-F3CC6H4; R1 = Me), II (R = 4-F3CC6H4), and III (R = 4-F3CC6H4) emerged as potent Bcr/Abl kinase inhibitors. Hence, the potent compounds that arose out of this investigation are potential lead mols. to develop as an alternative to existing dasatinib therapy. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3HPLC of Formula: 638-07-3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.HPLC of Formula: 638-07-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics