Sun, Haiyan et al. published their research in Youji Huaxue in 2018 | CAS: 95-88-5

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 4-Chlororesorcinol

Lead optimization and antiproliferative activity using a new dithiocarbamates substructure was written by Sun, Haiyan;Sun, Hongshun;Liu, Mingzhen;Huang, Wei;Yang, Guangfu. And the article was included in Youji Huaxue in 2018.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

In this work, a series of dithiocarbamate derivatives bearing diverse quinazolinones I (R = bis(propan-2-yl)aminyl, pyrrolidin-1-yl, methyl(phenyl)aminyl, etc.; X = H, Cl), benzoxazinones II, and coumarin moieties III (R1 = H, OH; R2 = H, Cl; R3 = OH; R4 = H, Me, OH; R3R4 = -CH=CH-CH=CH-) was designed and synthesized via a one-pot three-component reaction. These compounds I, II, III produced good yields and functioned quickly under mild conditions, and the desired products were readily isolated. Their in vitro antitumor activities were evaluated by the Me thiazolyl tetrazolium (MTT) method against hepatoma carcinoma cells HCCLM-7, cervical carcinoma cells Hela, mammary adenocarcinoma cells MDA-MB-435S, colon carcinoma cells SW-480, laryngocarcinoma cells Hep-2, and mammary adenocarcinoma cells MCF-7. Three compounds were identified as the most promising candidates, due to their high potency and broad-spectrum antiproliferative activity (IC50:3.5∼13.5μmol·L-1). The activities of some lead compounds were more than 10-fold more potent than that of pos. control 5-fluorouracil (5-FU) (IC50:8.1∼128.7μmol·L-1). These results indicated that the dithiocarbamate (DTC) derivatives bearing fused heterocyclic moieties could be used as lead for further developing new antitumor active compounds This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics