A sandwich-type electrochemical immunosensor using trimetallic nanozyme as signal amplification for NT-proBNP sensitive detection was written by Zhang, Bin;Li, Fei;Han, Feng;Yang, Haixia;Jiang, Chenglong;Tan, Siheng;Tu, Jinchun;Qiao, Bin;Wang, Xiaohong;Wu, Qiang. And the article was included in Bioelectrochemistry in 2022.HPLC of Formula: 13820-53-6 The following contents are mentioned in the article:
Heart failure (HF) is a major public health problem trigged by a heart circulation disorder. Early detection and diagnosis are conducive to the prevention and treatment of HF. N-terminal B-type natriuretic peptide precursor (NT-proBNP) is considered to be a sensitive diagnostic biomarker of HF. In this study, we constructed a NT-proBNP sandwich electrochem. immunosensor by using electroplated gold nanoparticles (Au NPs) as the substrate and utilizing rough-surfaced trimetallic Au@PdPt nanozymes (Au@PdPt RTNs) as current signal amplification. The Au NPs as substrate material modified glassy carbon electrode (GCE) have excellent conductivity and biocompatibility, which not only accelerate electron transfer rate, but also improve the loading capacity of primary antibody (Ab1). Moreover, the Au@PdPt RTNs were synthesized by a one-pot method and used as the labels to bound with secondary antibodies (Ab2) via the Pt-N. The large sp. surface area and excellent catalytic properties for H2O2 of Au@PdPt RTNs can effectively enhance the stability and sensitivity of the immunosensor. With the favorable cooperation of Au NPs and Au@PdPt RTNs, the constructed immunosensor exhibited a wide concentration range from 0.1 pg mL-1 to 100 ng mL-1 and a low detection limit of 0.046 pg mL-1. Furthermore, the accuracy of the anal. of NT-proBNP in diluted human serum samples was satisfactory. The results revealed the electrochem. immunosensor has a prospective application in clin. detection. This study involved multiple reactions and reactants, such as Sodium tetrachloropalladate(II) (cas: 13820-53-6HPLC of Formula: 13820-53-6).
Sodium tetrachloropalladate(II) (cas: 13820-53-6) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.HPLC of Formula: 13820-53-6
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics