Reversible Control of Protein Localization in Living Cells Using a Photocaged-Photocleavable Chemical Dimerizer was written by Aonbangkhen, Chanat;Zhang, Huaiying;Wu, Daniel Z.;Lampson, Michael A.;Chenoweth, David M.. And the article was included in Journal of the American Chemical Society in 2018.Product Details of 6294-17-3 The following contents are mentioned in the article:
Many dynamic biol. processes are regulated by protein-protein interactions and protein localization. Exptl. techniques to probe such processes with temporal and spatial precision include photoactivatable proteins and chem. induced dimerization (CID) of proteins. CID has been used to study several cellular events, especially cell signaling networks, which are often reversible. However, chem. dimerizers that can be both rapidly activated and deactivated with high spatiotemporal resolution are currently limited. Herein, we present a novel chem. inducer of protein dimerization that can be rapidly turned on and off using single pulses of light at two orthogonal wavelengths. We demonstrate the utility of this mol. by controlling peroxisome transport and mitotic checkpoint signaling in living cells. Our system highlights and enhances the spatiotemporal control offered by CID. This tool addresses biol. questions on subcellular levels by controlling protein-protein interactions. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Product Details of 6294-17-3).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Product Details of 6294-17-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics