Dimers of coumarin-1,2,3-triazole hybrids bearing alkyl spacer: Design, microwave-assisted synthesis, molecular docking and evaluation as antimycobacterial and antimicrobial agents was written by Ashok, Dongamanti;Gundu, Srinivas;Aamate, Vikas Kumar;Devulapally, Mohan Gandhi;Bathini, Raju;Manga, Vijjulatha. And the article was included in Journal of Molecular Structure in 2018.Category: chlorides-buliding-blocks The following contents are mentioned in the article:
The present study demonstrated the synthesis of new series of coumarin-1,2,3-triazole hybrids under microwave irradiation method. Several dimers of coumarin based 1,2,3-triazole derivatives were synthesized and their antimycobacterial and antimicrobial activities were investigated. The antimycobacterial activity screening results revealed that compounds I (R = Cl; n = 6, 8) were the most active against Mycobacterium tuberculosis H37Rv strain. The active compounds were further evaluated for cytotoxicity with HEK cell lines and exhibited less % of inhibition. The same synthetic hybrids were evaluated for their antimicrobial activity against various bacterial strains and fungal strains and compounds I (R = H, n = 8; R = Cl, n = 5, 6, 8) were found to be the most promising antimicrobial potent mols. Furthermore, the active compounds against Mycobacterium tuberculosis were evaluated for their mol. docking studies against pantothenate synthetase (PS) enzyme of MTB and the docking results are in well agreement with the antitubercular evaluation results. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Category: chlorides-buliding-blocks).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics