Bouchmaa, Najat et al. published their research in Archiv der Pharmazie (Weinheim, Germany) in 2018 | CAS: 89938-53-4

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 89938-53-4

Cytotoxicity of new pyridazin-3(2H)-one derivatives orchestrating oxidative stress in human triple-negative breast cancer (MDA-MB-468) was written by Bouchmaa, Najat;Ben Mrid, Reda;Boukharsa, Youness;Nhiri, Mohamed;Ait Mouse, Hassan;Taoufik, Jamal;Ansar, M’hammed;Zyad, Abdelmajid. And the article was included in Archiv der Pharmazie (Weinheim, Germany) in 2018.HPLC of Formula: 89938-53-4 The following contents are mentioned in the article:

Triple-neg. breast cancer (TNBC) is a complex and aggressive subtype of breast cancer characterized by high morbidity and mortality. In the absence of targeted therapy, only chemotherapy is available in this case of cancer. The current study investigated the antitumor effect of new pyridazin-3(2H)-one derivatives on the human TNBC cell line, MD-MB-468. The in vitro cytotoxic activities were investigated using the tetrazolium-based MTT assay. Lipid peroxidation, H2O2 content, and the specific activities of antioxidant enzymes were also determined Two mols., 6f and 7h, were found to be selectively highly active against tumor cells with IC50 values of 3.12 and 4.9 μM, resp. Furthermore, cells exposed to 6f showed a significant increase in H2O2 and lipid peroxidation levels, accompanied by a decrease in the enzyme activities of glutathione reductase (GR) and thioredoxin reductase (TrxR). The cytotoxicity of the compound 6f may improve the therapeutic efficacy of the current treatment for TNBC via the inhibition of GR and TrxR activities. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4HPLC of Formula: 89938-53-4).

3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.HPLC of Formula: 89938-53-4

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics