Dai, Hong et al. published their research in European Journal of Medicinal Chemistry in 2019 | CAS: 95-88-5

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Excellent antitumor and antimetastatic activities based on novel coumarin/pyrazole oxime hybrids was written by Dai, Hong;Huang, Meiling;Qian, Jianqiang;Liu, Ji;Meng, Chi;Li, Yangyang;Ming, Guxu;Zhang, Ting;Wang, Senling;Shi, Yujun;Yao, Yong;Ge, Shushan;Zhang, Yanan;Ling, Yong. And the article was included in European Journal of Medicinal Chemistry in 2019.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:

A series of hybridsbased on coumarin/pyrazole oxime I (n = 1, 2; R = 3-F, 4-I, 2-CH3, etc.) have been synthesized, and exhibited good to excellent antitumor activities. Compound I (n = 2; R = 4-Cl) has shown remarkable anticancer effect on SMMC-7721 cells (IC50 = 2.08 μM), which is considerably lower than 5-FU (IC50 = 37.8 μM) and similar to ADM (IC50 = 2.67 μM), with little effect on normal hepatic cells LO2. Notably, the suppression experiments of metastatic activities reveal that I (n = 2; R = 4-Cl) also displays significant anti-metastasis effects through inhibiting cell migration and invasion in highly metastatic SMMC-7721 cell line, and dose-dependently reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) procedure better than ADM. Finally, I (n = 2; R = 4-Cl) also possesses low acute toxicity and potent tumor growth inhibitory property against SMMC-7721 cell lines in vivo. These findings suggest that novel coumarin/pyrazole oxime hybrids are promising therapeutic agent candidates for further research. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).

4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Recommanded Product: 4-Chlororesorcinol

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics