Nickel-Catalyzed Asymmetric Domino Ring Opening/Cross-Coupling Reaction of Cyclobutanones via a Reductive Strategy was written by Ding, Decai;Dong, Haiyan;Wang, Chuan. And the article was included in iScience in 2020.Computed Properties of C6H12BrCl The following contents are mentioned in the article:
The successful application of reductive strategy in the asym. domino ring opening/cross-coupling reaction of prochiral cyclobutanones I (R = Me, Et, n-Pr; R1 = H, Me, F, etc.; R2 = H, Me, OCH3) was demonstrated. Under the catalysis of a chiral nickel complex, various aryl iodide-tethered cyclobutanones I were reacted with alkyl bromides R3Br (R3 = 2-methoxyethyl, cyclopentyl, oxan-4-yl, etc.) as the electrophilic coupling partner, providing a variety of chiral indanones II bearing a quaternary stereogenic center in highly enantioselective manner, which can be further converted to diverse benzene-fused cyclic compounds including III, IV, V (X = O, NH). The preliminary mechanistic investigations support a mechanism involving Ni(I)-mediated enantiotopic C-C σ-bond activation of cyclobutanones as key elementary step in the catalytic cycle. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H12BrCl
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics