Qin, Yan-Li et al. published their research in Catalysis Letters in 2019 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate

A Novel Thermal Stable Carbonyl Reductase from Bacillus cereus by Gene Mining as Biocatalyst for β-Carbonyl Ester Asymmetric Reduction Reaction was written by Qin, Yan-Li;Ruan, Tao;Hou, He-Shuai;Hou, Ya-Li;Yang, Zhong-Hua;Quan, Can. And the article was included in Catalysis Letters in 2019.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:

Carbonyl reductase, as biocatalyst, is very important to chiral alcs. production through asym. reduction of carbonyl compound A novel thermal stable carbonyl reductase from Bacillus cereus (BcCR) dependent on NADPH was obtained through a new genome mining strategy proposed in this work. By analyzing its amino acid sequence and structure, the BcCR should be a thermal stability and wide pH tolerance carbonyl reductase. Its gene was cloned by PCR with B. cereus genomic DNA as template. Its heterologous expression system, E. coli BL21 (DE3) plysS/pET28a-bccr, was constructed, and BcCR was successfully expressed. Enzymic properties show that at 57.5 °C and pH 7.0 it can reach maximum reaction rate. Its Km and Vmax to Et 4-chloroacetoacetate is 1.85 mmol/L and 0.22 μmol/(min·mgprotein), resp. It can catalyze the asym. reduction of the β-carbonyl compound, such as Et 4-chloroacetoacetate to Et S-4-chloro-3-hydroxybutyrate. This paper proposes a practical method for discovery of new carbonyl reductases, and provides a novel enzyme as biocatalyst for asym. reduction of β-carbonyl compound This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Recommanded Product: Ethyl 4-chloro-3-oxobutanoate).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Recommanded Product: Ethyl 4-chloro-3-oxobutanoate

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics