Synthesis of substituted tetrahydropyrimidin-2-ones through nucleophilic cyclization/electrophilic substitution of 1-(3,3-diethoxypropyl)urea with C-nucleophiles was written by Smolobochkin, Andrey V.;Gazizov, Almir S.;Yakhshilikova, Lola J.;Sidlyaruk, Nikita A.;Khamatgalimov, Airat R.;Burilov, Alexander R.;Pudovik, Michail A.. And the article was included in Tetrahedron in 2022.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:
In this article, a regioselective method for the synthesis of new water-soluble 1,3,4-trisubstituted tetrahydropyrimidin-2(1H)-one derivatives I [R = Ph, 3-MeC6H4, 4-MeOC6H4, etc.; R1 = 2,4-di-OH-5-ClC6H2, 6-hydroxy-1,3-benzodioxol-5-yl, 3-carboxy-2,6-dihydroxy-Ph, 4-hydroxy-6-methyl-2-oxo-pyran-3-yl] containing sodium methanesulfonate fragment in the first position of the heterocycle was reported. The method was based on the reaction of (1-(3,3-diethoxypropyl)ureido)methanesulfonates (EtO)2CH(CH2)2N(CH2SO3Na)CONHR [R = Ph, 3-MeC6H4, 4-MeOC6H4, etc.] with aromatic and heterocyclic nucleophiles. The proposed method was distinguished by the possibility of obtaining a wide range of water-soluble substituted tetrahydropyrimidinones I, the absence of the need to use expensive metal complex catalysts, high product yield, and ease of purification This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Computed Properties of C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics