Wang, Fei et al. published their research in Journal of the American Chemical Society in 2021 | CAS: 6294-17-3

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 6294-17-3

Insertion of Diazo Esters into C-F Bonds toward Diastereoselective One-carbon Elongation of Benzylic Fluorides: Unprecedented BF3 Catalysis with C-F Bond Cleavage and Reformation was written by Wang, Fei;Nishimoto, Yoshihiro;Yasuda, Makoto. And the article was included in Journal of the American Chemical Society in 2021.Recommanded Product: 6294-17-3 The following contents are mentioned in the article:

Herein the BF3 -catalyzed formal insertion of diazo esters RC(=N2)C(O)OR1 (R = 2-methylphenyl, 4-chlorophenyl, 4-phenylphenyl, etc.; R1 = Me, prop-2-en-1-yl, 2-chloroethyl, adamantan-1-yl) and 4-diazoisochroman-3-one as one-carbon-atom sources into C-F bonds to accomplish one-carbon elongation of benzylic fluorides ArCH(F)R2 (Ar = Ph, 4-fluorophenyl, naphthalen-2-yl, etc.; R2 = Me, Pr, tetradecyl, 6-chlorohexyl) was reported. A DFT calculation study revealed that the BF3 catalyst could contribute to both C-F bond cleavage and re-formation. This elongation provided α-fluoro-α,β-diaryl esters (2R,3R)/(2R,3S)-ArCH(R2)C(F)(R)C(O)OR1 and (2R,3R)/(2R,3S)-4-(1-(4-chlorophenyl)ethyl)-4-fluoroisochroman-3-one with a high level of diastereoselectivity. Various benzylic fluorides and diazo esters were applicable. The synthetic utility of this method was demonstrated by the synthesis of a fluoro analog of a compound I that is used as a transient receptor and potential canonical channel inhibitor. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 6294-17-3).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 6294-17-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics