Wei, Ping et al. published their research in Molecular Catalysis in 2019 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H9ClO3

Significantly enhancing the biocatalytic synthesis of chiral alcohols by semi-rationally engineering an anti-Prelog carbonyl reductase from Acetobacter sp. CCTCC M209061 was written by Wei, Ping;Guo, Ze-Wang;Wu, Xiao-Ling;Liang, Shan;Ou, Xiao-Yang;Xu, Pei;Zong, Min-Hua;Yang, Ji-Guo;Lou, Wen-Yong. And the article was included in Molecular Catalysis in 2019.Computed Properties of C6H9ClO3 The following contents are mentioned in the article:

Chiral alcs. and their derivatives are vital building blocks to synthesize pharmaceutical drugs and high-valued chems. Wild-type carbonyl reductase AcCR from Acetobacter sp. has ideal enantioselectivity toward 11 prochiral substrates (e.e.>99%) but poor activity. In this work, a semi-rational engineering was performed to enhance the activity of AcCR. Fortunately, three pos. double-mutants (mut-E144A/G152L, mut-G152L/Y189 N, and mut-I147 V/G152L) with specific activity 17-61 folds higher than that of enzyme without modified were achieved. Kinetic studies suggested that the catalytic efficiencies (kcat/Km) of these mutants were also well enhanced. Finally, these modified mut-AcCRs were successfully applied in asym. reductions of 11 structurally diverse prochiral substrates (200 mM) with excellent product yields (76.8%-99.1%) and enantiomeric excess (e.e.>99%), which provides an alternative strategy for efficient synthesis of chiral alcs. for pharmaceuticals industry with ideal yield and enantioselectivity. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Computed Properties of C6H9ClO3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Computed Properties of C6H9ClO3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics