Nickel-catalyzed allylic carbonylative coupling of alkyl zinc reagents with tert-butyl isocyanide was written by Weng, Yangyang;Zhang, Chenhuan;Tang, Zaiquan;Shrestha, Mohini;Huang, Wenyi;Qu, Jingping;Chen, Yifeng. And the article was included in Nature Communications in 2020.SDS of cas: 6294-17-3 The following contents are mentioned in the article:
By leveraging easily accessible tert-Bu isocyanide as the CO surrogate, a nickel-catalyzed allylic carbonylative coupling with alkyl zinc reagent RZnX (R = Me, n-Bu, Bn, cyclopentyl, 2-chloropyridin-5-yl, etc.; X = Br, Cl), allowing for the practical and straightforward preparation of synthetically important β,γ-unsaturated ketones R1CH=C(R2)CH(R3)C(O)R (R1 = n-Pr, Ph, cyclohexyl, furan-2-yl, etc.; R2 = H, Me; R3 = H, Me, Et, cyclopropyl) in a linear-selective fashion with excellent trans-selectivity under mild conditions was described. Moreover, the undesired polycarbonylation process which is often encountered in palladium chem. could be completely suppressed. This nickel-based method features excellent functional group tolerance, even including the active aryl iodide functionality to allow the orthogonal derivatization of β,γ-unsaturated ketones. Preliminary mechanistic studies suggest that the reaction proceeds via π-allylnickel intermediate. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3SDS of cas: 6294-17-3).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.SDS of cas: 6294-17-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics