A New Discovery towards Novel Skeleton of Benzimidazole-Conjugated Pyrimidinones as Unique Effective Antibacterial Agents was written by Yang, Xi;Syed, Rasheed;Fang, Bo;Zhou, Cheng-He. And the article was included in Chinese Journal of Chemistry in 2022.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
A class of new potential antibacterial agents with distinctive pyrimidinone benzimidazole skeleton was developed through nucleophilic substitution and Biginelli reaction starting from urea, Et 4-chloroacetoacetate and various aldehydes. Some target mols. exhibited strong antibacterial activities, especially pyrimidinone benzimidazole hybrid 9e possessed the strongest inhibitory effects on the growth of E. faecalis and P. aeruginosa with a lower MIC value of 1 μg/mL than norfloxacin. Moreover, compound 9e displayed strong antibiofilm capacity, low drug resistance and excellent biosafety toward human red blood cells. Further research revealed that compound 9e could disrupt membrane integrity and cause leakage of cellular components such as proteins and nucleic acids. Meanwhile, compound 9e could decrease lactate dehydrogenase activity, block cell metabolism and interact with DNA in an intercalation manner. ADMET anal. predicated that mol. 9e possessed promising pharmacokinetic properties and good bioavailability profile. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Safety of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics