Colorimetric analysis of palladium using thiocarbamate hydrolysis and its application for detecting residual palladium in drugs was written by Choi, Myung Gil;Seo, Ju-Yeon;Cho, Eun Jin;Chang, Suk-Kyu. And the article was included in Journal of Photochemistry and Photobiology, A: Chemistry in 2022.Quality Control of 4-Chlororesorcinol The following contents are mentioned in the article:
In this research, we report a practical colorimetric method for the convenient anal. of residual palladium ions in drugs and drug intermediates. In a phosphate-buffered (pH 7.0) 50% aqueous DMSO solution, chlororhodol-based probe PP-1 demonstrated a prominent colorimetric (APP-1+Pd(II)/APP-1 at 531 nm is over 780) and turn-on type fluorescence signaling behavior (IPP-1+Pd(II)/IPP-1 at 561 nm is over 2000) toward palladium. The signaling was realized through the palladium-assisted hydrolysis of the thiocarbamate protecting moiety of the probe. Palladium-selective signaling was feasible in the presence of possibly interfering chem. species, and it was concluded within 7 min. The selective signaling was observed for palladium species with different oxidation states (Pd2+, Pd4+, and Pd0). The detection limit of the probe for palladium anal. was sufficiently sensitive to analyze the residual palladium in drugs and related products (LODPP-1 = 1.0 x 10-8 M, LODPP-2 = 4.3 x 10-8 M). In particular, palladium anal. could be performed in the presence of ibuprofen and 2-cyano-4â?methylbiphenyl, as the drug and drug intermediate, resp. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Quality Control of 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Quality Control of 4-Chlororesorcinol
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics