Reductive oxyamination: a method for the qualitative and quantitative analysis of monosaccharides with a new aminooxy reagent using high-performance liquid chromatography with fluorescence detection was written by Ding, Manman;Guan, Zhaobing;Cai, Hongwei;Huang, Yiyong;Lin, Yawei;Hu, Xiaosong. And the article was included in Analytical and Bioanalytical Chemistry in 2018.COA of Formula: C6H5ClO2 The following contents are mentioned in the article:
Derivatization of carbohydrates with aminooxy agents to form oximes can be used for qual. and quant. anal. of carbohydrates; however, the formation of isomeric products limits its application. A new reductive oxyamination procedure developed for the anal. of monosaccharides with a novel fluorescent O-substituted aminooxy reagent, 4-((aminooxy)methyl)-6-chloro-7-hydroxycoumarin (AOCC), is reported. In this procedure, monosaccharides undergo an oxime formation reaction with AOCC and are then readily reduced with 2-picoline-borane, followed by anal. with HPLC with fluorescence detection. Good separation of five monosaccharide derivatives was achieved within 40 min with acetonitrile-water-tetrahydrofuran as the mobile phase. The detection limits were on the order of femtomoles. The linear range was 0.2-4000 nM, with a good correlation coefficient (R ≥ 0.9985). Furthermore, the method was applied for anal. of real samples, such as bovine milk powder, without complicated and tedious sample treatment. This reductive oxyamination method circumvents the problem caused by oxime isomers and can be used for the highly sensitive and selective anal. of monosaccharides with high accuracy, providing an effective and promising method for the anal. of carbonyls with aminooxy agents. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5COA of Formula: C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorination modifies the physical properties of hydrocarbons in several ways. These compounds are typically denser than water due to the higher atomic weight of chlorine versus hydrogen. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.COA of Formula: C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics