Krall, Jacob et al. published their research in Journal of Medicinal Chemistry in 2019 | CAS: 638-07-3

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 638-07-3

Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic acid as a new class of ligands selective for the γ-hydroxybutyric acid (GHB) high-affinity binding sites was written by Krall, Jacob;Bavo, Francesco;Falk-Petersen, Christina B.;Jensen, Claus H.;Nielsen, Julie O.;Tian, Yongsong;Anglani, Valeria;Kongstad, Kenneth T.;Piilgaard, Louise;Nielsen, Birgitte;Gloriam, David E.;Kehler, Jan;Jensen, Anders A.;Harpsoee, Kasper;Wellendorph, Petrine;Froelund, Bente. And the article was included in Journal of Medicinal Chemistry in 2019.Application of 638-07-3 The following contents are mentioned in the article:

Gabazine, a γ-aminobutyric acid type A (GABAA) receptor antagonist, has previously been reported to inhibit the binding of [3H]NCS-382, a representative ligand of the high-affinity binding site for the neuroactive substance γ-hydroxybutyric acid (GHB). We herein report a study on the structural determinants of gabazine for binding to (i) the orthosteric binding site of the GABAA receptor and (ii) the high-affinity GHB binding site. Expanding the structural diversity of available ligands for the high-affinity GHB binding sites, this study identified 2-(imidazo[1,2-b]pyridazin-2-yl)acetic acid as a novel ligand-scaffold leading to analogs with relatively high affinity (Ki 0.19-2.19 μM) and >50 times selectivity for the [3H]NCS-382 over [3H]muscimol binding sites. These results highlight that gabazine interacts with the high-affinity GHB and orthosteric GABAA receptor binding sites differently and that distinct analogs can be generated to select between them. To facilitate further in vivo studies, a promising prodrug candidate for brain delivery was identified. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application of 638-07-3).

Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 638-07-3

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics