A Rationally Designed, General Strategy for Membrane Orientation of Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes was written by Kulkarni, Rishikesh U.;Yin, Hang;Pourmandi, Narges;James, Feroz;Adil, Maroof M.;Schaffer, David V.;Wang, Yi;Miller, Evan W.. And the article was included in ACS Chemical Biology in 2017.SDS of cas: 95-88-5 The following contents are mentioned in the article:
Voltage imaging with fluorescent dyes offers promise for interrogating the complex roles of membrane potential in coordinating the activity of neurons in the brain. Yet, low sensitivity often limits the broad applicability of optical voltage indica-tors. In this paper, the authors use mol. dynamics (MD) simulations to guide the design of new, ultra-sensitive fluorescent voltage indicators that use photoinduced electron transfer (PeT) as a voltage-sensing switch. MD simulations predict an approx. 16% increase in voltage sensitivity resulting purely from improved alignment of dye with the membrane. The authors confirm this theor. finding by synthesizing 10 new voltage-sensitive (VoltageFluor, or VF) dyes and establishing that all of them display the expected improvement of approx. 19%. This synergistic outworking of theory and experiment enabled computational and theor. estimation of VF dye orientation in lipid bilayers and has yielded the most sensitive PeT-based VF dye to date. The authors use this new voltage indicator to monitor voltage spikes in neurons from rat hippocampus and human pluripotent stem cell-derived dopaminergic neurons. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5SDS of cas: 95-88-5).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 95-88-5
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics