Synthesis and Characterization of Potential Related Substances of the Antiplatelet Agent Clopidogrel Bisulfate was written by Metil, Dattatray S.;Sampath, Aalla;Reddy, Ch. Venkata Ramana;Bandichhor, Rakeshwar. And the article was included in ChemistrySelect in 2018.Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate The following contents are mentioned in the article:
Synthesis of antiplatelet agent clopidogrel bisulfate (I) used for the treatment of platelet aggregation to prevent blood clotting. During the laboratory process development of clopidogrel bisulfate, there was identification of six potential related substances methyl-2-(2-amino-2-(2-chlorophenyl)acetamido)-2-(2-chlorophenyl)acetate, Me 2-(bis (2-(thiophen-2-yl)ethyl)amino)-2-(2-chlorophenyl) acetate hydrochloride, Me (S)-2-(2-chlorophenyl)-2-(methyl(2-(thiophen-2-yl)ethyl)amino)acetate, (S)-methyl-2-(2-chlorophenyl)-2-(2-(hydroxymethyl)-6,7-dihydrothieno[3,2-c]pyridin5(4H)-yl)acetatebisulfate, (S)-methyl-2-(2-chlorophenyl)-2-(2-(hydroxymethyl)-6,7-dihydrothieno[3,2-c] pyridin-5(4H)-yl), (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c] pyridine-2-sulfonic acid which were formed at various stages of the preparation of clopidogrel bisulfate. Out of these, three related substances methyl-2-(2-amino-2-(2-chlorophenyl)acetamido)-2-(2-chlorophenyl)acetate, Me 2-(bis(2-(thiophen-2-yl)ethyl)amino)-2-(2-chlorophenyl) acetate hydrochloride, (S)-5-(1-(2-chlorophenyl)-2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-sulfonic acid were found to be unprecedented. The present work detailed the synthesis of these related substances by employing efficient synthetic strategies and also their control strategies during clopidogrel manufacturing This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate).
(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics