Improved Production of 5-Hydroxymethylfurfural in Acidic Deep Eutectic Solvents Using Microwave-Assisted Reactions was written by Morais, Eduarda S.;Freire, Mara G.;Freire, Carmen S. R.;Silvestre, Armando J. D.. And the article was included in International Journal of Molecular Sciences in 2022.Application In Synthesis of Tetramethylammonium chloride The following contents are mentioned in the article:
Hydroxymethylfurfural (5-HMF) is a key platform chem., essential for the production of other chems., as well as fuels. Despite its importance, the production methods applied so far still lack in sustainability. In this work, acidic deep eutectic solvents (DES), acting both as solvent and catalyst, were studied for the conversion of fructose into 5-HMF using microwave-assisted reactions. These solvents were screened and optimized by varying the hydrogen bond donor (HBD) and hydrogen bond acceptor (HBA). The bio-based solvent γ-valerolactone (GVL) was also applied as additive, leading to a boost in 5-HMF yield. Then, a response surface methodol. was applied to further optimize operating conditions, such as reaction time, temperature and weight% of added GVL. The highest 5-HMF yield attained, after optimization, was 82.4% at 130°C, in 4 min of reaction time and with the addition of 10 weight% of GVL. Moreover, a process for 5-HMF recovery and DES reuse was developed through the use of the bio-based solvent 2-methyltetrahydrofuran (2-Me-THF), allowing at least three cycles of 5-HMF production with minimal yield losses, while maintaining the purity of the isolated 5-HMF and the efficacy of the reaction media. This study involved multiple reactions and reactants, such as Tetramethylammonium chloride (cas: 75-57-0Application In Synthesis of Tetramethylammonium chloride).
Tetramethylammonium chloride (cas: 75-57-0) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Application In Synthesis of Tetramethylammonium chloride
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics