Evolving a Unique Red-Emitting Fluorophore with an Optically Tunable Hydroxy Group for Imaging Nitroreductase in Cells, in Tissues, and in Vivo was written by Peng, Rong;Yuan, Jie;Cheng, Dan;Ren, Tianbing;Jin, Fangping;Yang, Ronghua;Yuan, Lin;Zhang, Xiaobing. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2019.Recommanded Product: 95-88-5 The following contents are mentioned in the article:
Fluorescence mol. imaging has attracted more and more attention due to its various advantages. Lots of fluorophores have been developed to meet various mol. imaging needs. However, it is still inconvenient due to lack excellent fluorophores with an optically tunable group for biol. mol. imaging. Here, a new platform of the versatile long wavelength fluorophore with an optically tunable hydroxyl group was successfully developed by regulating mol. planarity and twisted intramol. charge transfer effect with protected and deprotected-hydroxyl group approach via “step by step” modifying strategy. As an excellent representative of this new type fluorophore, LDOH-4 performs good chem. and optical properties, and shows a potential application prospect. As a proof-of-concept, a nitroreductase-activated TP fluorescent probe LDO-NTR was designed, which not only sensitively recognize NTR with more than 310-fold response signal enhancement in vitro, but also tracking NTR in hypoxia tumor mouse in vivo by using two-photon imaging. It is hopeful that the long wavelength fluorophore with the optically tunable hydroxyl group can serve as a useful platform to extend capable detection tools in biol. chem. and biomedical applications. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 95-88-5).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Recommanded Product: 95-88-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics