Mitochondrial-targeted near-infrared fluorescence probe for selective detection of fluoride ions in living cells was written by Xu, Xiaobo;Chen, Wen;Yang, Mei;Liu, Xian-Jun;Wang, Fenglin;Yu, Ru-Qin;Jiang, Jian-Hui. And the article was included in Talanta in 2019.Product Details of 95-88-5 The following contents are mentioned in the article:
Fluoride ions (F–), as a strongest electron withdrawing anion of the smallest size, have played an indispensable role in biol. systems. Here a mitochondria-targeted near-IR (NIR) fluorescent probe (Mito-FP) is developed for selective detection of F– in living cells. Mito-FP is designed using a NIR hemicyanine as a fluorophore and tert-butyldimethylsilyl (TBDMS) as a recognition site which is linked to the fluorophore via a 4-hydroxylbenzyl alc. self-immolative linker. Mito-FP is essentially nonfluorescent. F– can specifically cleave the Si-O bond which triggers the elimination of the quinone methide intermediate and generates the initial NIR hemicyanine fluorophore with distinct intramol. charge transfer and activated fluorescence signal. The Mito-FP probe is responsive to the concentrations of F– in the range of 10-120μM with an estimated limit of detection of 3.2μM. Mito-FP also exhibits high selectivity toward F– with good stability in the physiol. pH conditions. Mito-FP is successfully introduced to detect and image F– in HeLa cells. Moreover, Mito-FP is also demonstrated to exhibit excellent mitochondrial-targeting ability. This NIR fluorescence probe could provide a useful tool for studying F– in mitochondria. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Product Details of 95-88-5).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Product Details of 95-88-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics