Angona, Irene Pachon et al. published their research in International Journal of Molecular Sciences in 2020 | CAS: 6294-17-3

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C6H12BrCl

Synthesis of Hantzsch adducts as cholinesterases and calcium flux inhibitors, antioxidants and neuroprotectives was written by Angona, Irene Pachon;Martin, Helene;Daniel, Solene;Moraleda, Ignacio;Bonet, Alexandre;Wnorowski, Artur;Maj, Maciej;Jozwiak, Krzysztof;Iriepa, Isabel;Refouvelet, Bernard;Marco-Contelles, Jose;Ismaili, Lhassane. And the article was included in International Journal of Molecular Sciences in 2020.Computed Properties of C6H12BrCl The following contents are mentioned in the article:

We report herein the design, synthesis, biol. evaluation, and mol. modeling of new inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE), able to block Ca+2 channels also showing antioxidant and neuroprotective activities. The new MTDL, dialkyl 2,6-dimethyl-4-(4-((5-aminoalkyl)oxy)phenyl)-1,4-dihydropyridine-3,5-dicarboxylate 3a-p, have been obtained via Hantzsch reaction from appropriate and com. available precursors. Pertinent biol. anal. has prompted us to identify MTDL 3h [dimethyl-4-(4-((5-(4-benzylpiperidin-1-yl)pentyl)oxy)phenyl)-2,6-dimethyl-1,4-dihydropyridine3,5-dicarboxylate] as an attractive inhibitor of AChE (1.8μM) and BuChE (2μM), Ca+2 channel antagonist (47.72% at 10μM), and antioxidant (2.54 TE) agent, showing significant neuroprotection 28.68% and 38.29% against H2O2, and O/R, resp., at 0.3μM, thus being considered a hit-compound for further investigation in our search for anti-Alzheimer’s disease agents. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Computed Properties of C6H12BrCl).

1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Computed Properties of C6H12BrCl

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics