Steglich′s Base Catalyzed Three-Component Synthesis of Isoxazol-5-Ones was written by Faramarzi, Zeinab;Kiyani, Hamzeh. And the article was included in Polycyclic Aromatic Compounds.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
4-(Dimethylamino)pyridine (DMAP) was used as an efficient Bronsted organo-base catalyst for the one-pot, three-component cyclization of various aldehydes, β-keto esters and hydroxylamine hydrochloride. In this organocatalyzed reaction, 3,4-disubstituted isoxazole-5(4H)-ones were efficiently formed in high yields and relatively shorter reaction times. Using 8 mol% of DMAP, a mixture of water-ethanol solvent system and 80 °C gave the best results. The three-component heterocyclization using arylaldehydes containing electron releasing groups was well performed and heterocyclic products were obtained in good to high isolated yields. Aldehydes with electron withdrawing groups did not lead to the formation of products. This method has many advantages such as broad substituent scope, mild and eco-friendly conditions, step and atom economy, com. available and inexpensive organo-basic catalyst. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Safety of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics