Synthesis of several 4H-chromene derivatives of expected antitumor activity was written by Fouda, Ahmed M.. And the article was included in Medicinal Chemistry Research in 2016.COA of Formula: C6H5ClO2 The following contents are mentioned in the article:
Multi-component reactions for the preparation of 4H-chromene derivatives under microwave irradiation from different aromatic aldehydes with a mixture of malononitrile and phenol derivatives were established. The cytotoxic activity of the target compounds was evaluated against four cancer cell lines MCF-7, HCT-116, HepG-2 and A549 in comparison with vinblastine and colchicine as reference drugs. Generally, several compounds showed good cell growth inhibitory activity as compared to standard drugs. The structure-activity relationship studies reported that the substitution at 4- and 6-positions in 4H-chromene nucleus with the specific halogen atom increases the ability of the mol. against the different cell lines. The structures of the synthesized compounds were established on the basis of spectral data, IR, 1H NMR, 13C NMR and MS data. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5COA of Formula: C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics