Evaluation of 5H-Thiazolo[3,2-α]pyrimidin-5-ones as Potential GluN2A PET Tracers was written by He, Yingfang;Whitehead, David M.;Briard, Emmanuelle;Numao, Shin;Mu, Linjing;Schibli, Roger;Ametamey, Simon M.;Auberson, Yves P.. And the article was included in ChemMedChem in 2020.Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
The authors describe their efforts to develop a PET tracer for imaging GluN2A-containing NMDA receptors, based on a 5H-thiazolo[3,2-α]pyrimidin-5-one scaffold. The metabolic stability and overall properties were optimized satisfactorily, although binding affinities remained a limiting factor for in vivo imaging. The authors identified [18F]pyrimidinone I as a radioligand providing good-quality images in autoradiog. studies, as well as [3H2]pyrimidinylcyclopropanecarbonitrile II, which was used for the successful development of a radioligand binding assay. These are valuable new tools for the study of GluN2A-containing NMDA receptors, and for the optimization of allosteric modulators binding to the pharmacophore located at the dimer interface of the GluN1-GluN2A ligand-binding domain. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Application In Synthesis of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics