Designed Boron-Rich Polymeric Nanoparticles Based on Nano-ion Pairing for Boron Delivery was written by Li, Jianwei;Janouskova, Olga;Fernandez-Alvarez, Roberto;Mesikova, Sona;Tosner, Zdenek;Kereiche, Sami;Uchman, Mariusz;Matejicek, Pavel. And the article was included in Chemistry – A European Journal in 2020.Synthetic Route of C25H54ClN The following contents are mentioned in the article:
Boron-rich particles with the boron fraction ca.10-20 wt % of controllable shape and size that can be easily prepared via simple ion co-assembly are promising material for tumor treatment by boron neutron capture therapy. Electroneutral, dynamic core-shell polymeric nanoparticles were prepared by co-assembly of cationic PEO-block-PGEA diblock copolymer with sodium closo-dodecaborate, Na2[B12H12]. This is the first example of polymer nanoparticles based on [B12H12]2-nano-ion pairing. The high [B12H12]2- loading is proven by calorimetry at physiol. salt concentration As a result of rational design, rod-, worm- and sphere-like particles were produced and further tested using human glioblastoma and cervical carcinoma cell lines. Rod-like particles yielded the highest internalization capability in all tested cell lines. This study involved multiple reactions and reactants, such as N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3Synthetic Route of C25H54ClN).
N-Methyl-N,N-dioctyloctan-1-aminium chloride (cas: 5137-55-3) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Organochlorine compounds are lipophylic, meaning they are more soluble in fat than in water. This gives them a high tenancy to accumulate in the food chain (biomagnification).Synthetic Route of C25H54ClN
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics