Tandem Reaction of 4-Halo-1,3-Dicarbonyl Compounds with Alkynes towards 4-Vinyl-3(2H)-Furanones and 3(2H)-Furanone fused 2-Pyridones was written by Omanakuttan, Vishnu K.;Santhini, P. V.;Shaludheen, S.;Varughese, Sunil;Hopf, Henning;John, Jubi. And the article was included in Asian Journal of Organic Chemistry in 2022.Related Products of 638-07-3 The following contents are mentioned in the article:
A facile synthetic route of 4-vinyl-3(2H)-furanones I [R1 = OMe, OEt, OtBu, Ph; R2 = H, C(O)Ph, CO2Me, CO2tBu; R3 = H, Me; R4 = H, Me, Br; R5 = OMe, OEt, Ph] via tandem Michael addition and intramol. cyclization from the reaction of 4-halo-1,3-dicarbonyl compounds and alkynes was reported. The formation of a side-product (regioisomer) by a stepwise [2+2] cycloaddition between enolate (of the 4-halo-1,3-dicarbonyl compound) and activated alkyne followed by a sequential 4π-ring opening and an intramol. cyclization was also noted. Another interesting observation was the formation of 3(2H)-furanone fused 2-pyridone II [R6 = Me, Et; R7 = Ph, Bn, 4-MeC6H4, etc.] from the reaction of 4-bromo-3-oxo-N-alkyl(aryl)butanamides and activated alkynes with satisfactory to good yields. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Related Products of 638-07-3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Related Products of 638-07-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics