The amylase inhibitor montbretin A reveals a new glycosidase inhibition motif was written by Williams, Leslie K.;Zhang, Xiaohua;Caner, Sami;Tysoe, Christina;Nguyen, Nham T.;Wicki, Jacqueline;Williams, David E.;Coleman, John;McNeill, John H.;Yuen, Violet;Andersen, Raymond J.;Withers, Stephen G.;Brayer, Gary D.. And the article was included in Nature Chemical Biology in 2015.Category: chlorides-buliding-blocks The following contents are mentioned in the article:
The complex plant flavonol glycoside montbretin A (MbA) is a potent (Ki = 8 nM) and specific inhibitor of human pancreatic α-amylase (HPA) with potential as a therapeutic for diabetes and obesity. Controlled degradation studies on montbretin A, coupled with inhibition analyses, identified an essential high-affinity core structure comprising the myricetin and caffeic acid moieties linked via a disaccharide. X-ray structural analyses of the montbretin A complex with human α-amylase confirmed the importance of this core structure and revealed a novel mode of glycosidase inhibition, wherein internal π-stacking interactions between the myricetin and caffeic acid moieties organize their ring hydroxyls for optimal hydrogen bonding to the α-amylase catalytic residues D197 and E233. This novel inhibitory motif can be reproduced in a greatly simplified analog, offering potential for new strategies for glycosidase inhibition and therapeutic development. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Category: chlorides-buliding-blocks).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. The haloform reaction, using chlorine and sodium hydroxide, is also able to generate alkyl halides from methyl ketones, and related compounds. Chloroform was formerly produced thus.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics