An efficient ultrasonic-assisted synthesis of enol carbamates via oxidative coupling of formamides with 1,3-dicarbonyl compounds was written by Akbari, Jafar;Meyestani, Alireza Akbari. And the article was included in Letters in Organic Chemistry in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
Sonochem. oxidative-coupling of N,N-dimethyl/diethylformamide with 1,3-dicarbonyl compounds RC(O)CH(R1)C(O)OR2 (R = Me, chloromethyl, Ph, propyl; R1 = H, Cl; R2 = Me, Bn, prop-2-en-1-yl, etc.) in the corresponding carbamates R2OC(O)C(R1)=C(R)OC(O)N(R3)(R4) (R3 = R4 = Me, Et) by CuO nanoparticles as a catalyst and tert-Bu hydroperoxide (TBHP) as an oxidant has been reported. Various derivatives of enol carbamates were synthesized with good to high yields under the optimized reaction conditions. Compared with conventional methods, the main advantage of this method is mild conditions. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Name: Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics