Application of a Ferrocene-Based Palladacycle Precatalyst to Enantioselective Aryl-Aryl Kumada Coupling was written by Arthurs, Ross A.;Hughes, David L.;Richards, Christopher J.. And the article was included in European Journal of Inorganic Chemistry in 2022.Safety of Sodium tetrachloropalladate(II) The following contents are mentioned in the article:
The palladium catalyzed reaction of 1-iodo-2-methylnaphthalene and 2-methyl-1-naphthylmagnesium bromide gave quant. an (Sa)-configured cross-coupled product in 80% e.e. using (R,Sp)-PPFA as a ligand. N,N-Dimethylaminomethylferrocene was cyclopalladated (Na2PdCl4, (S)-Ac-Phe-OH, 93% e.e., as determined by 1H NMR as a result of self-induced non-equivalence), and the resulting (Sp)-configured dimeric palladacycle was employed as a precatalyst for this cross-coupling reaction (5 mol%). Addition to the palladacycle of diphenylphosphine and subsequent base-promoted bidentate ligand synthesis and palladium capture gave an in situ generated catalyst resulting in an (Sp)-configured product in up to 71% e.e. This study involved multiple reactions and reactants, such as Sodium tetrachloropalladate(II) (cas: 13820-53-6Safety of Sodium tetrachloropalladate(II)).
Sodium tetrachloropalladate(II) (cas: 13820-53-6) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Aliphatic organochlorides are often alkylating agents as chlorine can act as a leaving group, which can result in cellular damage.Safety of Sodium tetrachloropalladate(II)
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics