Efficient nicotinamide adenine dinucleotide phosphate [NADP(H)] recycling in closed-loop continuous flow biocatalysis was written by Baumer, Benedikt;Classen, Thomas;Pohl, Martina;Pietruszka, Joerg. And the article was included in Advanced Synthesis & Catalysis in 2020.Name: Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
Biocatalytic redox reactions regularly depend on expensive cofactors that require recycling. For continuous conversions in flow chem., this is often an obstacle since the cofactor is washed away. Here, we present a quasi-stationary recycling system for NADP utilizing an immobilized alc. dehydrogenase. Four model substrates were reduced with high enantioselectivity as a proof of concept. The two-phase system enables continuous production as well as quick substrate changes. This setup may serve as a general cofactor regeneration module for continuous biocatalytic devices employing (co-)substrates being miscible in organic solvent. The system resulted in space-time yields up to 117 g L-1 h-1 and total turnover numbers for NADP higher than 12,000 mol/mol are possible. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Name: Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Name: Ethyl 4-chloro-3-oxobutanoate
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Chloride – Wikipedia,
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