Iron-catalyzed arene C-H hydroxylation was written by Cheng, Lu;Wang, Huihui;Cai, Hengrui;Zhang, Jie;Gong, Xu;Han, Wei. And the article was included in Science (Washington, DC, United States) in 2021.Computed Properties of C6H5ClO2 The following contents are mentioned in the article:
Report of iron coordinated by a bioinspired l-cystine-derived ligand catalyzed undirected arene carbon-hydrogen hydroxylation with hydrogen peroxide as the terminal oxidant to afford aryl alcs. Ar-OH [Ar = Ph, N-(phenyl)acetamide, tert-butyl(phenyl)carbamate, etc.]. The reaction was distinguished by its broad substrate scope, excellent selectivity, good yields, and it showcased compatibility with oxidation-sensitive functional groups, such as alcs., polyphenols, aldehydes and even a boronic acid. This method was well suited for the synthesis of polyphenols through multiple carbon-hydrogen hydroxylations, as well as the late-stage functionalization of natural products and drug mols. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Computed Properties of C6H5ClO2).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Computed Properties of C6H5ClO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics