Amine synthesis via iron-catalysed reductive coupling of nitroarenes with alkyl halides was written by Cheung, Chi Wai;Hu, Xile. And the article was included in Nature Communications in 2016.Recommanded Product: 1-Bromo-6-chlorohexane The following contents are mentioned in the article:
The reductive coupling of nitroarenes RNO2 (R = 4-OHC6H4, OHCH2CH2C6H4, 1-naphthyl, etc.) with alkyl halides R1X (R1 = butan-2-yl, oxolan-3-yl, cyclooctyl, etc.) to yield (hetero)aryl amines, e.g., I has been reported. A simple iron catalyst enables the coupling with numerous primary, secondary and tertiary alkyl halides. Broad scope and high functional group tolerance are demonstrated. Mechanistic study suggests that nitrosoarenes and alkyl radicals are involved as intermediates. This new C-N coupling method provides general and step-economical access to aryl amines. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Recommanded Product: 1-Bromo-6-chlorohexane).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Recommanded Product: 1-Bromo-6-chlorohexane
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics