The Highly Regioselective Synthesis of Novel Imidazolidin-2-ones via the Intramolecular Cyclization/Electrophilic Substitution of Urea Derivatives and the Evaluation of Their Anticancer Activity was written by Gazizov, Almir S.;Smolobochkin, Andrey V.;Kuznetsova, Elizaveta A.;Abdullaeva, Dinara S.;Burilov, Alexander R.;Pudovik, Michail A.;Voloshina, Alexandra D.;Syakaev, Victor V.;Lyubina, Anna P.;Amerhanova, Syumbelya K.;Voronina, Julia K.. And the article was included in Molecules in 2021.Reference of 95-88-5 The following contents are mentioned in the article:
A series of novel 4-(het)arylimidazolidin-2-ones I [R = 5-Cl-2,4-di-HO-C6H2, 6-hydroxy-1,3-benzodioxol-5-yl, 4-hydroxy-6-methyl-2-oxo-pyran-3-yl; R1 = H, Me; R2 = Ph, 4-MeC6H4, 3-ClC6H4, etc.] was obtained by the acid-catalyzed reaction of (2,2-dimethoxyethyl)ureas with aromatic and heterocyclic C-nucleophiles. The proposed approach to substituted imidazolidinones I benefited from excellent regioselectivity, readily available starting materials and a simple procedure. The regioselectivity of the reaction was rationalized by quantum chem. calculations and control experiments The anti-cancer activity of the obtained compounds was tested in vitro. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Reference of 95-88-5).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Reference of 95-88-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics