An improved synthesis of clopidogrel bisulfate was written by Hu, Jia-peng;Lu, Xin;Liu, Zhi-bin. And the article was included in Zhejiang Huagong in 2012.Product Details of 141109-14-0 The following contents are mentioned in the article:
(S)-Me 2-amino-2-(2-chlorophenyl) acetate is obtained from racemic 2-amino-2-(2-chlorophenyl) acetic acid through esterification and optical resolution, which was subjected to condensation reaction with 2-(thiophen-2-yl)ethyl 4-Me benzene sulfonate to afford the critical intermediate (S)-Me 2-(2-chlorophenyl)-2-(2-thiophen-2-yl)ethylamino) acetate. The cyclization of (S)-Me 2-(2-chloropheny)-2-(2-(thiophen-2-yl) ethylamino) acetate with paraformaldehyde in the presence of anhydrous formic acid provided clopidogrel bisulfate. For this synthesis pathway, there are some advantages such as readily available starting material, moderate condition, high yield and good quality. This process is suitable for industrialization. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Product Details of 141109-14-0).
(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organochlorines are organic compounds having multiple chlorine atoms. They were the first synthetic pesticides that were used in agriculture. They are resistant to most microbial and chemical degradations. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Product Details of 141109-14-0
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics