Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H2O: An Expedient Way to Access Alkyl Amides was written by Li, Qiao;Jin, Hongwei;Liu, Yunkui;Zhou, Bingwei. And the article was included in Synthesis in 2020.Application of 6294-17-3 The following contents are mentioned in the article:
Herein, a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanide and water to access alkyl amides I [R = Et, cyclohexyl, CH2(CH2)2Ph, etc.] was described. Bench-stable NiCl2(dppp) was competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process was proposed based on preliminary experiments and previous literature. This study involved multiple reactions and reactants, such as 1-Bromo-6-chlorohexane (cas: 6294-17-3Application of 6294-17-3).
1-Bromo-6-chlorohexane (cas: 6294-17-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin.While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available. Alkyl chlorides readily undergo attack by nucleophiles.Application of 6294-17-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics