An unexpected synthesis and application of ethyl 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate was written by Li, Yang;Dong, Shiyu;Tang, Bingyue;Zou, Hongtao;Jiang, Wenting. And the article was included in Research on Chemical Intermediates in 2020.SDS of cas: 638-07-3 The following contents are mentioned in the article:
An unexpected and direct synthesis of Et 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate from the chlorotrimethylsilane-promoted Friedlander reaction between 1-(2-amino-5-iodophenyl)ethanone and Et 4-chloro-3-oxobutanoate has been disclosed. As a versatile and attractive building block, a synthetic application of the Et 2,4-bis(chloromethyl)-6-iodoquinoline-3-carboxylate in the successive Williamson ether synthesis with various phenols 2-R-3-R1-4-R2-C6H2OH (R = H, Me, Cl, t-Bu, etc.; R1 = H, Br; R2 = H, Me, Cl, Br, t-Bu) and in situ ester hydrolysis reaction has been achieved and the corresponding 2,4-bis(aroxymethyl)quinoline-3-carboxylic acids I were obtained in good yields of 71-86%. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3SDS of cas: 638-07-3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.SDS of cas: 638-07-3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics