Synthesis and antiviral activity of nonannulated tetrazolylpyrimidines was written by Ostrovskii, Vladimir A.;Danagulyan, Gevorg G.;Nesterova, Olga M.;Pavlyukova, Yulia N.;Tolstyakov, Vladimir V.;Zarubina, Olga S.;Slepukhin, Pavel A.;Esaulkova, Yana L.;Muryleva, Anna A.;Zarubaev, Vladimir V.;Trifonov, Rostislav E.. And the article was included in Chemistry of Heterocyclic Compounds in 2021.COA of Formula: C6H9ClO3 The following contents are mentioned in the article:
Nonannulated tetrazolylpyrimidines in the structure of which the heterocyclic fragments were separated by hydrazinocarbonylmethyl I [R = H, Me], methylpyrazolyl II, groups or a sulfur atom III [R1 = Ph; R2 = H; R1 = CH2CO2H, R2 = Me] were synthesized. Some of these compounds showed moderate in vitro activity against H1N1 subtype of influenza A virus. The selectivity index of the anti-influenza action of {5-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-1H-tetrazol-1-yl}acetic acid, which had very low cytotoxicity, was twice as high as the selectivity index of the reference drug rimantadine. This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3COA of Formula: C6H9ClO3).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Chlorinated organic compounds are found in nearly every class of biomolecules and natural products including alkaloids, terpenes, amino acids, flavonoids, steroids, and fatty acids. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.COA of Formula: C6H9ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics