A Novel Inhibitor of the Obesity-Related Protein FTO was written by Qiao, Yan;Zhou, Bin;Zhang, Meizi;Liu, Weijia;Han, Zhifu;Song, Chuanjun;Yu, Wenquan;Yang, Qinghua;Wang, Ruiyong;Wang, Shaomin;Shi, Shuai;Zhao, Renbin;Chai, Jijie;Chang, Junbiao. And the article was included in Biochemistry in 2016.Recommanded Product: 4-Chlororesorcinol The following contents are mentioned in the article:
FeII and α-ketoglutarate-dependent fat mass and obesity associated protein (FTO)-dependent demethylation of m6A is important for regulation of mRNA splicing and adipogenesis. Developing FTO-specific inhibitors can help probe the biol. of FTO and unravel novel therapeutic targets for treatment of obesity or obesity-associated diseases. In the present paper, we have identified that 4-chloro-6-(6′-chloro-7′-hydroxy-2′,4′,4′-trimethyl-chroman-2′-yl)benzene-1,3-diol (CHTB) is an inhibitor of FTO. The crystal structure of CHTB complexed with human FTO reveals that the novel small mol. binds to FTO in a specific manner. The identification of the novel small mol. offers opportunities for further development of more selective and potent FTO inhibitors. This study involved multiple reactions and reactants, such as 4-Chlororesorcinol (cas: 95-88-5Recommanded Product: 4-Chlororesorcinol).
4-Chlororesorcinol (cas: 95-88-5) belongs to organic chlorides. Organic chlorides can be used in production of: PVC, pesticides, chloromethane, teflon, insulators. Alkyl chlorides readily react with amines to give substituted amines. Alkyl chlorides are substituted by softer halides such as the iodide in the Finkelstein reaction.Recommanded Product: 4-Chlororesorcinol
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