Shaw, Scott A. et al. published their research in Journal of Organic Chemistry in 2015 | CAS: 141109-14-0

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Synthesis of Biologically Active Piperidine Metabolites of Clopidogrel: Determination of Structure and Analyte Development was written by Shaw, Scott A.;Balasubramanian, Balu;Bonacorsi, Samuel;Cortes, Janet Caceres;Cao, Kevin;Chen, Bang-Chi;Dai, Jun;Decicco, Carl;Goswami, Animesh;Guo, Zhiwei;Hanson, Ronald;Humphreys, W. Griffith;Lam, Patrick Y. S.;Li, Wenying;Mathur, Arvind;Maxwell, Brad D.;Michaudel, Quentin;Peng, Li;Pudzianowski, Andrew;Qiu, Feng;Su, Shun;Sun, Dawn;Tymiak, Adrienne A.;Vokits, Benjamin P.;Wang, Bei;Wexler, Ruth;Wu, Dauh-Rurng;Zhang, Yingru;Zhao, Rulin;Baran, Phil S.. And the article was included in Journal of Organic Chemistry in 2015.Category: chlorides-buliding-blocks The following contents are mentioned in the article:

Clopidogrel (I) is a prodrug anticoagulant with active metabolites that irreversibly inhibit the platelet surface GPCR P2Y12 and thus inhibit platelet activation. However, gaining an understanding of patient response has been limited due to imprecise understanding of metabolite activity and stereochem., and a lack of acceptable analytes for quantifying in vivo metabolite formation. Methods for the production of all bioactive metabolites of clopidogrel (II, mixture of four stereoisomers), their stereochem. assignment, and the development of stable analytes via three conceptually orthogonal routes are disclosed. This study involved multiple reactions and reactants, such as (S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0Category: chlorides-buliding-blocks).

(S)-Methyl 2-amino-2-(2-chlorophenyl)acetate (cas: 141109-14-0) belongs to organic chlorides. Organic chlorides can cause corrosion in pipelines, valves and condensers, and cause catalyst poisoning. The hydrocarbon processing industry (HPI) and others are affected by damage caused by these substances. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst.Category: chlorides-buliding-blocks

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics