Cerium(IV) based oxidative free radical cyclization of active methylene compounds with some cyclic alkenes: A useful annulation method for terpene functionalization was written by Svetlik, Jan;Turecek, Frantisek;Hartwich, Katarzyna;Koziel, Krzysztof;Pakulski, Pawel;Palasz, Aleksandra;Kalinowska-Tluscik, Justyna;Ciez, Dariusz. And the article was included in Tetrahedron in 2019.Safety of Ethyl 4-chloro-3-oxobutanoate The following contents are mentioned in the article:
Ceric ammonium nitrate-mediated oxidative cyclizations of CH-acids with terpenes and terpene-like substrates were investigated. Dimedone, acetylacetone, and Me nitroacetate were condensed with pinene, norbornene, nopol, camphene, and carvone and the reaction stereoselectivity was examined Condensation with endocyclic double bonds in pinene and nopol displayed stereoselectivity, resulting in the formation of pure enantiomers. Condensation with exocyclic double bonds in camphene and carvone produced enantiomer mixtures The mechanism of the intramol. annulation in a nopol derivative is discussed with the help of DFT and ab initio calculations This study involved multiple reactions and reactants, such as Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3Safety of Ethyl 4-chloro-3-oxobutanoate).
Ethyl 4-chloro-3-oxobutanoate (cas: 638-07-3) belongs to organic chlorides. Organochlorines stimulate the central nervous system and cause convulsions, tremor, nausea, and mental confusion. Examples are dichlorodiphenyltrichloroethane (DDT), chlordane, lindane, endosulfan, and dieldrin. Alkyl chlorides are versatile building blocks in organic chemistry. While alkyl bromides and iodides are more reactive, alkyl chlorides tend to be less expensive and more readily available.Safety of Ethyl 4-chloro-3-oxobutanoate
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics