The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates was written by Wang, Jane L.;Aston, Karl;Limburg, David;Ludwig, Cindy;Hallinan, Ann E.;Koszyk, Francis;Hamper, Bruce;Brown, David;Graneto, Matthew;Talley, John;Maziasz, Timothy;Masferrer, Jaime;Carter, Jeffery. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Reference of 89938-53-4 The following contents are mentioned in the article:
In this manuscript, we report the discovery of the substituted 2-trifluoromethyl-2H-benzopyran-3-carboxylic acids as a novel series of potent and selective cyclooxygenase-2 (COX-2) inhibitors. We provide the structure-activity relationships, optimization of design, testing criteria, and human half-life data. The challenge of a surprisingly long half-life (t 1/2 = 360 h) of the first clin. candidate 1 and human t 1/2 had been difficult to predict based on allometric scaling for this class of highly ppb compounds We used a microdose strategy which led to the discovery of clin. agents 18c-(S), 29b-(S), and 34b-(S) with human half-life of 57, 13, and 11 h. This study involved multiple reactions and reactants, such as 3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4Reference of 89938-53-4).
3-Chloro-2-hydroxy-5-methylbenzaldehyde (cas: 89938-53-4) belongs to organic chlorides. An organic chloride is an organic compound containing at least one covalently bonded atom of chlorine. Their wide structural variety and divergent chemical properties lead to a broad range of names and applications. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control.Reference of 89938-53-4
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics